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KMID : 0604520210470020133
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Journal of the Society of Cosmetic Scientists of Korea
2021 Volume.47 No. 2 p.133 ~ p.138
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Design of Solid Lipid Nanoparticles to Improve Penetration of Niacinamide through Artificial Skin Tissue
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Yeo Soo-Ho
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Abstract
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In this study, Niacinamide (NI) was loaded into solid lipid nanoparticles (SLNs) and skin permeability was evaluated to improve skin permeability of NI, which was a skin whitening substance. NI was able to effectively load within SLN with a double-melting emulsification method, producing stable particles with average particle sizes of 263.30 to 436.93 nm and a zeta potential of -34.77 to -57.60 mV. Artificial skin tissue (SkinEthicTM RHE) derived from skin keratinocytes derived from human epidermal tissue was used for the skin permeation study of NI. Skin transmittance and deposition experiments of NI confirmed that all SLN formulations improved skin transmittance and deposition rates of NI, approximately 5.4 ∼ 7.6 and 9.5 ∼ 20.8 improvement over SLN applications. Therefore, SLN manufactured in this study have shown sufficient results to improve the skin permeability of the functional whitening substance, NI.
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KEYWORD
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niacinamide, solid lipid nanoparticles, skin whitening, skin penetration, SkinEthicTM RHE
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